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KMID : 0043319980210010012
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Archives of Pharmacal Research
1998 Volume.21 No. 1 p.12 ~ p.16
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Inhibitory Effect of Lignans from the Rhizomes of Coptis japonica var. dissecta on Tumor Necrosis Factor- Production in Lipopolysaccharide-stimulated RAW264.7 Cells
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Cho Jae-Youl
Park Ji-Soo
Yoo Eun-Sook
Kazuko Yoshikawa
Baik Kyong-Up
Lee Jong-Soo
Park Myung-Hwan
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Abstract
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The inhibitory effect of 10 lignan constituents isolated from the rhizomes of Coptis japonica var. dissects on tumor necrosis factor (TNF)- production in lipopolysaccharide (LPS)-stimulated macrophage cell line (RAW264.7 cells) has been studied. Among them, pinoresinol, woorenoside-V and lariciresinol glycoside showed significant inhibitory activities in the range from 37% to 55% at the concentration of The results are first report that the lignans isolated from Coptis japonica inhibit TNF- ${\alpha}$
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KEYWORD
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TNF-α, RAW264.7, LPS, Coptis japonica, Lignam, Pinoresinol, Woorenoside, Lariciresinol glycoside, ELISA
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